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Conjugation can be either enzymic or non-enzymatic, nevertheless, GSH transferases are widespread in both animals and plants, and enzymatic conjugation is assumed to be particularly effective and may even result in GSH depletion

Oxidation: Copper ions can catalyze oxidation reactions

Perakakis N, Stefanakis K, Feigh M, Veidal SS, Mantzoros CS

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Subsequently, SAM contributes two electrons because MS is unable to take the two electrons from the MTHF, preventing the creation of a net SAM [117, 118], (Fig