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Increased levels of oxidized proteins and nitrated tyrosine residues within the -synuclein have been found in Lewy bodies in patients with PD

The analogous isoforms in mice are VEGF120, VEGF164 and VEGF188 [234,250]

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Sleep, by contrast, enhances the clearance of toxic metabolites from the brain, including ROS, as well as abnormal protein aggregates, such as amyloid- [224]

Strengths and limitations Strengths of this study are the use of a large, unselected study population from routine clinical practice that comprises almost all patients with type 2 diabetes in Sweden, and the use of nationwide registers that provide high-quality data on prescription drug use, diagnoses registered during hospitalisation and outpatient visits, and clinical variables such as BMI and HbA 1c , as well as markers of socioeconomic status