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Discontinue GTE if ALT or AST exceeds 1.5 times the upper limit of normal (a more conservative threshold than the iPLEDGE hold criteria, given the additive exposure)

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The idea is supported by maintenance of functional GSH/GSSG levels by Sp in BSO and neurotoxin treated cells as compared to untreated ones which showed a significant decline in the antioxidant ratio probably, due to enhanced formation of glutathionequinones 43

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