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It supports microbial diversity and may reduce bloating by reducing low-grade inflammation and gut dysbiosis

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Others find they need a lower maintenance dose indefinitely to prevent hunger signals from returning

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Nonetheless, early evidence did suggest that mechanisms sensitive to loop diuretics, possibly involving NKCC1 and/or KCCs, may contribute to the phosphorylation of numerous protein substrates in the liver (Lang et al., 1998)