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204,207 These results raise the possibility that RNAP II and mtRNAPs might function as both sensors and executors, which sense NAD + /NADH ratios and induce the NAD + capping to regulate the gene expression, leading to the crosstalk between cellular NAD + metabolism and transcriptional activity

The other, in whom only 5% is available to cells, is not

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At the very least, immunogenicity would trigger the production of antibodies that neutralize the peptides effects