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PLoS Pathog 6 , e1001242, doi: 10.1371/journal.ppat.1001242 (2011)

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Hormonal markers (especially for women): estradiol, progesterone, total and free testosterone, SHBG, DHEA-S, tracked against cycle phase where applicable

Blood Pressure Health (150 mg/daily) Pycnogenol's positive effects on NO production and endothelial function help promote normal blood pressure

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Other Factors that Impact Manufacturing Route: Non-natural Complexity: Peptide complexity is a major determinant for manufacturing approach