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The mechanisms underlying IGF-1's tendon repair effects involve activation of the IGF-1 receptor on tenocytes and tendon stem cells, leading to enhanced extracellular matrix synthesis, improved cellular migration to injury sites, and optimized remodeling of repair tissue
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The rats (n = 4) were trained to discriminate between different concentrations of sugar and water using a homegustometer, and their performance was recorded continuously for up to 23 hours daily
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By influencing S-adenosylmethionine (SAM) levels, it also plays a role in epigenetic regulation and longevity-related gene expression, linking energy metabolism with cellular lifespan
