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Initial investigations focused on the metabolic stability of various Nle-AngIV-derived peptides in rat serum

Glutathione is a critical component of the immune system, as it is an important intracellular water-soluble antioxidant.* As part of this function, glutathione plays a vital role as the cofactor for the antioxidant enzymes glutathione peroxidase and glutathione transferase

however, theoretical risks include off-target activation of the HGF/c-Met pathway, which is implicated in oncogenesis, warranting caution regarding long-term use

Sci Rep 5 , 10637 (2015)

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Animals were kept in a hypotensive state for one hour to enforce the organ dysfunction