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Metformin should be temporarily stopped during acute illness, severe dehydration, or before procedures requiring iodinated contrast media, and restarted only when renal function is stable

"Scientific Opinion on the safety of caffeine." 2015

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I had developed an isolated perfused, as it is called, pancreas a surviving pancreas that would produce insulin if stimulated, and so we could put this new peptide that we had isolated on this pancreas and see if it produced insulin, and it did

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