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Because of its structural difference from natural GLP-1, it is not easy to be degraded by dipeptidyl peptidase-4 (DPP-4), thus prolonging the action time
doi: 10.1038/s41392-021-00470-1 133 KangI.ChangM
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Additionally, the administration of oral GLP-1 drugs requires strict guidance: for example, semaglutide must be taken on an empty stomach in the morning, with no more than 120 mL of water, and patients must wait at least 30 minutes before having breakfast
Surg 1921, 74, 498500
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