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Previous experiments by our group have shown that retinal degeneration in EAAC1 KO mice was suppressed by administration of edaravone, a free radical scavenger, and spermidine, a polyamine with an antioxidant property 11,13

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193 When muscles contract and generate force, these signals can prompt changes in gene expression and protein synthesis within fibroblasts, enhancing the ligaments resilience and repair capabilities

The presence of FAD-binding region and transmembrane hemes enable NOXs to act as an electron-transportation chain that transfers two electrons from cytosolic NADPH to extracellular O 2 , resulting in the generation of O 2

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