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Effect of physical exercise training on muscle strength and body composition, and their association with functional capacity and quality of life in patients with atrial fibrillation: a randomized controlled trial

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Besides their central importance for the catabolic turnover of macromolecules, lysosomes also fulfill a critical anabolic function by serving as a recruitment platform for the multisubunit nutrient-sensing and signaling mechanistic target of rapamycin complex 1 (mTORC1), a major driver of anabolic programs, such as protein and lipid biosynthesis 4,5

areas that commonly suffer during calorie restriction.