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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

These findings suggest a powerful capacity for dermal thickening and structural improvement, which is highly relevant for softening the appearance of acne scars

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Moreover, the optimal dosing strategy for this combination has not been established