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The compound triggers a process the downstream benefits depend on how much senescent cell burden existed, how efficiently the immune system clears debris, and how effectively tissues regenerate
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The most common GLP-1 receptor agonists on the market include medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)
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NHS England and NICE have proposed a 20 million threshold : if a new drug is expected to cost the NHS more than 20m per year in the first 3 years, it triggers mandatory negotiation of access schemes to manage uptake ( [23] )
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