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The stability problem is one reason why people in the UK are much better off with German hydroxocobalamin

PMID 12643357

Tablets: Injections (Hydroxocobalamin): Provide a direct and immediate increase in Vitamin B12 levels

It can cause spina bifida, paralysis, and even completely prevent the brain from developing

This is especially beneficial for those who may struggle to get adequate B12 through diet alone, including vegetarians, vegans, or those with certain digestive issues

Lyophilized powder freezes fine for long-term storage, but once a peptide is in solution, ice crystals physically damage the structure you lose potency and get precipitation on thaw