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Additionally, NADH can be generated by fatty acid oxidation (FAO) in the cytoplasm in tissues with high energy demand, such as cardiac muscle tissues, as well as in cancer cells 141

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Any shortage of active B6 (P-5-P), required by Glutamate Decarboxylase (GAD), further compromises production of GABA from glutamate

Key considerations include: Under-dosing risks: Insufficient receptor engagement may yield minimal benefit