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The physiological implications of the differential signalling profiles between GLP1 and oxyntomodulin are difficult to examine in vivo as oxyntomodulin cross reacts with the glucagon receptor and both peptides have short circulatory halflives

Medication-specific factors significantly impact onset of action

Despite its widespread use in cell culture studies, SLC7A11 inhibitor Erastin cannot be used for animal studies due to its poor metabolic stability and low solubility in vivo [13]

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