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The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

They are not general chemical surveys

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& Abdel-Rahman, R

Many patients experience benefits

Current work investigating the involvement of CBD and the endocannabinoid receptors is rapidly expanding, however there is still debate as to which of these effects are feasible at physiologic consumption levels of CBD