Role of alpha-cell GLP-1 production in metabolic dysfunction Alpha-cell GLP-1 production as an adaptive response to metabolic dysfunction Although the in vivo physiological function of intra-islet GLP-1 has been questioned since levels of GLP-1 in the pancreas of healthy mice are considerably low and sometimes undetected (5, 83), metabolic stress has been reported to potently increase alpha-cell-derived GLP-1 and decrease L-cell-derived GLP-1 in rodents and humans (18, 58, 8490)
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Whether GLP-1 medications have direct or indirect effects on the menstrual cycle independent of weight loss is a question researchers are now better positioned to study, in part because of work like this
2f) and insulin sensitivity, as assessed using hyperinsulinaemic-euglycaemic clamps (Fig
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A key physiological difference between the two incretin hormones, GIP and GLP-1, is therefore, that GIP is able to stimulate glucagon secretion, whereas GLP-1 suppresses glucagon secretion (18)
