glp-1 vs sglt2 weight loss differences seen between glucagon-like peptide–1 receptor agonists and sodium–glucose cotransporter–2 inhibitors for treatment of type 2 diabetes GLP-1R Agonists for Weight Loss

Last reviewed: June 15, 2026 Last updated: June 15, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Youll get 24/7 messaging with licensed providers, a dedicated Care Team, and unlimited dosage adjustments, plus access to FDA-approved GLP-1 medications when prescribed

The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals

Tirzepatide and retatrutide are also glucose-dependent insulinotropic polypeptide (GIP) agonists

Obesity is a chronic condition like high blood pressure, elevated cholesterol or high blood sugar and requires chronic treatment, said lead author Dr

they lack real-world evidence