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Minoxidil's mechanism a systemic vasodilator with no follicle specificity means side effects can extend well beyond the scalp: unwanted facial hair, scalp irritation, contact dermatitis, and (in rare cases) cardiovascular changes from systemic absorption.6 GHK-Cu, as an endogenous peptide acting locally on the cells where it's applied, has no documented systemic side effects and no withdrawal phenomenon when discontinued
The increased expression of CHOP leads to the down-regulation of B-cell lymphoma-2 (Bcl-2) gene expression, an anti-apoptotic protein, and increases the burden of new proteins in the ER, thereby promoting ER stress and cell death (Feldman et al., 2005)
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