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Healthcare providers may recommend GLP-1 medications for those struggling with long-term weight management when other methods are ineffective

How Strong Is the Evidence, Claim by Claim

dose reduction of these concomitant agents is often necessary Thyroid C-cell tumors : Based on rodent studies, GLP-1 receptor agonists carry a boxed warning regarding medullary thyroid carcinoma risk and are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Intestinal obstruction/ileus : Rare cases have been reported with some agents

Between-group comparison showed no significant difference for CTX, p = 0.08 ( p- value based on the log transformation), corresponding to relative changes of 9.96% and 2.02%, or for P1NP, p = 0.12 ( p- value based on the log transformation), corresponding to 1.23% and 1.15%, respectively

doi: 10.1056/NEJM199011153232001

Therefore, they may suppress the ability to fall in love