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Pharmacol Rev (2014) 66(1):179

Data show that deficiency of claudin-5 and occludin in cortical brain regions associated with AD further drives a loss of adhesion between TJs (Yamazaki et al., 2019)

Never freeze reconstituted peptidesice crystal formation irreversibly damages peptide structure

H3R antagonists such as ciproxifan have also been effective in enhancing alertness and memory [60], alleviating repetitive behavior in VPA-exposed mice [62], and correcting aberrant histamine-modulated neural activity in the cortico-basal ganglia circuitry [63,64] (Figure 1)

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