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These pathways involve integrins, which are transmembrane proteins that connect the ECM to the cytoskeleton

The local anaesthetic agent within the injectate may act on the nociceptive fibres , whereas corticosteroids may reduce inflammation

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doi: 10.1089/jmf.2019.4580

Quality of life and occupational disability in endocrine orbitopathy

Their potential mechanism of action would be the inhibition of prostaglandins and cytokines, including endothelin 1 and granulocyte macrophage colony-stimulating factor (GM-CSF), which are the main stimulators of melanin production (Ebanks et al., 2009)