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In the LIVE trial, liraglutide treatment resulted in no change in left ventricular systolic function, whereas liraglutide related to an increase in heart rate and more serious cardiac adverse events among chronic heart failure patients with and without type 2 diabetes [45]

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Both Novo Nordisk and Eli Lilly have invested heavily in expanding manufacturing infrastructure for oral GLP-1 therapies, including facilities across North Carolina, Texas, Alabama, and Puerto Rico