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102 Magnesium Magnesium plays an important role in regulating glucose metabolism and insulin sensitivity, and low magnesium status may be a contributing factor in the progression of insulin resistance to type 2 diabetes and heart disease

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These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects