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Studies have shown that exogenous administration of recombinant human IGF-I (51, 52) and IGF-I/IGFBP-3 complex (5355) improved insulin sensitivity and decreased insulin requirements in both T1D and T2D patients

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Reduces inflammation and supports antioxidant defenses

Minireview: Cns mechanisms of leptin action

377 However, owing to the role of Notch in normal tissue homeostasis, on-target gastrointestinal toxicity has limited the clinical application of Notch signaling inhibitors