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It is a cyclic peptide analog derived from melanotan II, which itself is related to alpha-melanocyte-stimulating hormone, or -MSH

Our findings are in agreement with other recent observations using similar ligature models, which show a considerable increase of the distance between the cemento-enamel junction and the alveolar crest, regarded as a sign of alveolar bone loss (48, 52)

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Brains were collected on ice, post-fixed in 4 C PFA 4% overnight and cryoprotected in sucrose 30% for 23 days

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Most side effects are mild and temporary