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A report from the EMAs PRAC, published on 12 April 2024, said: After reviewing the available evidence from non-clinical studies, clinical trials, post-marketing surveillance data and the available studies the PRAC considers that no update to the product information is warranted. The PRAC statement said that market authorisation holders would continue to monitor events, including new studies, as part of their pharmacovigilance activities

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Finally, there is no evidence in humans that exogenous lipoic acid can be 'activated' with ATP or GTP and incorporated into lipoic acid-dependent enzymes by a lipoyl transferase (14)

Smaldone, M

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The inclusion of KPV further supports immune regulation and anti-inflammatory pathways, expanding the experimental scope of this blend in preclinical settings