Many patients experience reduced appetite and fluid intake when starting GLP-1 therapy, whilst the medicine's gastrointestinal effects including nausea and occasional vomiting can further affect hydration status
While GLP-1 drugs can result in 15-25% total body weight loss, surgery often achieves 25-35% or more, with higher rates of long-term maintenance and remission of related diseases
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Last reviewed: May 14, 2026 Last updated: May 14, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Mechanism of Action Retatrutide works by activating three different hormone receptors: GLP-1, GIP, and glucagon