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That is the bull case for our Second-Order Effects, after all - those materialize most significantly when the penetration in the patient population is highest

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1) Core toxicology: a narrow physiologic buffer at the top of the therapeutic range Metabolic pathway: ~9095% is detoxified via glucuronidation and sulfation

Free Radic Res 23:91101 Purucker E, Lutz J (1992) Effect of hyperbaric oxygen treatment and perfluorochemical administration on glutathione status of the lung

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