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Unlike statins, which can cause myopathy through effects on muscle cell membranes and mitochondrial function, GLP-1 agonists do not have a known direct myotoxic mechanism
Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery
Semaglutide injections at 7.2mg achieved the highest CEI (0.86), followed by orforglipron 36mg (0.68), and injected semaglutide at 2.4mg (0.66)
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At the tissue level, GLP-1 agonists diminish ectopic fat accumulation in the liver and muscle, enhancing insulin sensitivity
