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Mechanistically, GLP-1 signaling suppresses M1-associated genes while enhancing that of M2-related genes through activation of signal transducer and activator of transcription 3 (STAT3) (Wan and Sun, 2019)

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Diabetes Care 34 , 132138 (2011)

In ALS, HGF treatment prevents excitotoxic insult through the enhanced expression of glutamate transporter 1 in astrocytes and subsequent clearance of the excessive glutamate (Sun et al., 2002

Severity ranges from mild (self-resolving) to severe (organ failure, 15-20% mortality)