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UK clinics and patients now have substantial real-world experience with prescribing, titration, and follow-up, alongside the original evidence from the STEP programme and ongoing use in practice

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Fluorescence microscopy studies have documented rapid cellular accumulation, with detectable intracellular concentrations within 30 minutes of external application at physiological concentrations

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Then cells were treated with gradient concentrations of NSBSO, NCSBSO, NS or BSO for another 12 h or 24 h