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62,65 Periodontal Disease Periodontal disease, an inflammatory and infectious disease affecting the gums and bone that support the teeth, may contribute to NAFLD

Advantages: Continuous appetite suppression Prevents weight regain during transition Preferred by patients with history of rapid rebound eating Disadvantages: Higher nausea and vomiting risk (estimated 35% vs 22% in first 2 weeks) Overlapping GLP-1 activation may transiently worsen gastroparesis symptoms Difficult to distinguish semaglutide vs tirzepatide side effects during overlap window Clinical data supporting overlap: a 2024 case series (Garvey et al., Journal of Clinical Endocrinology & Metabolism) described 89 patients who used 3-day overlap

So, think about any health conditions/diseases you have or ever had is there anything that would put you at risk

Administration of 25 mg empagliflozin after intake of a high-fat and high-calorie meal resulted in slightly lower exposure

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PubMed Han J, Warshaw EM