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Histological hallmarks of AxD are the emergence of perivascular Rosenthal fibres consisting of ubiquinated aggregates of GFAP, vimentin, small heat shock proteins -crystallin and Hsp27, and plectin

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There was no association observed for GLP1 receptor agonist use with an increased risk for thyroid cancer (hazard ratio, 0.93

An updated Cochrane review in 2019 of four studies with 907 participants was very uncertain as to if ALC caused a pain reduction after 6 to 12 months of treatment