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Through this modification, protein function and transcriptional programs are modulated, crucially influencing cellular physiology, tumorigenesis, and immune regulation (6)

Lysosome dysfunction as a cause of neurodegenerative diseases: lessons from frontotemporal dementia and amyotrophic lateral sclerosis

Initially, injections are given daily or every other day for a week, then weekly for 12 months, followed by monthly maintenance

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1 Like most complex genomic regulatory systems, Nrf2 (nuclear factor erythroid 2-related factor 2) is sequestered in the cytoplasm until it is able to translocate into the nucleus, where it forms a heterodimer with MAF (another transcription factor) and binds to the promoter region of genes containing an antioxidant response element (ARE) sequence