Mast Cell Activation Syndrome Treatment Conventional treatment for mast cell activation syndrome generally involves the use of pharmaceutical and over-the-counter medications to alleviate symptoms, such as the following medications: Epinephrine (such as an EpiPen) for severe reactions First generation H1 blockers diphenhydramine (Benadryl) and hydroxyzine (Vistaril) Second generation H1 blockers, including loratadine (Claritin), cetirizine (Zyrtec), and fexofenadine (Allegra) H2 blockers, such as ranitidine (Zantac) and famotidine (Pepcid) Aspirin, to block production of prostaglandin D2 and reduce flushing
Due to low skin tolerability, 3 patients discontinued the trial
[DOI] [PubMed] [Google Scholar] 295.Ward NE
If the answer to any of these raises concerns, a fresh vial may be warranted
These are often considered first-line options because they work gently and don't cause dependence with regular use
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