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As pH-dependent dissociation of ligand-receptor complexes within acidic endosomes is known to influence post-endocytic receptor sorting (Borden et al., 1990), we wondered if the impact of low pH might specifically affect interactions made by the positively charged lixisenatide C-terminus, modulating intra-endosomal binding and thereby explaining its different recycling rate

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The evidence is not practice-changing in isolation, but given the safety profile and prevalence of subclinical deficiency, magnesium supplementation represents one of the more defensible perimenopause interventions

Other side effects are very rare