PMID: 18728662
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2 Mechanisms of Parkinsons disease The aetiology and pathogenesis of PD involve abnormal aggregation of -synuclein (-syn), mitochondrial dysfunction, oxidative stress, and neuroinflammation (Figure 1)
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104,105,106 Over a decade ago, an in vitro study revealed that a combination of specific transcription factorsGATA4, MEF2C and TBX5 (collectively referred to as the GMT cocktail)could directly reprogram fibroblasts into functional cardiomyocytes, bypassing the conventional iPSC stage