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Marked anabolism occurred in mice over-expressing IGF-I (Coleman, Demayo, Yin et al., 1995) and IGF-I administration (3060 g/kg twice a day, ~36008600 g/day based on reported mean body weight) improved whole body and muscle protein synthesis in elderly women (Butterfield, Thompson, Rennie et al., 1997)

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Patients who take any medications should make his/ her healthcare professional aware that he/ she is considering starting Orlistat before beginning the tablets so that appropriate dosage adjustments and monitoring can be arranged