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Jankowski J, Perry HM, Medina CB, Huang L, Yao J, Bajwa A, et al

An important distinction from the FDA criteria is that the WHO guideline does not extend its recommendation to adults with a BMI between 27 and 30 who have obesity-related conditions

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2019;8: e012244

Medication Response and Receptor Dynamics While true pharmacological tolerance to GLP-1 receptor agonists appears limited based on current evidence, individual variation in receptor expression, desensitization patterns, and downstream signaling may influence long-term response

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