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This is due to increased small intestinal sodium/glucose cotransporter 1 (SGLT1) expression and subsequent GLP-1 release following intestinal glucose infusion, which are mediated by metformin-induced alterations in the small intestinal microbiota 131

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By comparing these patients to those using other diabetes drugs, including insulin, metformin, DPP-4 inhibitors, SGLT2 inhibitors, sulfonylureas, and thiazolidinediones, the study investigated the incidence of pancreatic cancer over 15 years