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WEDNESDAY, July 23, 2025 (HealthDay News) -- Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are associated with reduced type 2 diabetes mellitus (T2DM)-related dementia risk compared with metformin, according to a study published online July 22 in BMJ Open Diabetes Research & Care.Mingyang Sun, from the People's Hospital of Zhengzhou University in China, and colleagues conducted a retrospective cohort study using data from a global health research network between 2004 and 2024 to examine the comparative effectiveness of GLP-1 RAs and metformin in reducing dementia risk
Thus, receptors with the intracellular domain of IGF1R showed increased activation of Shc and Gab-1 and more potent regulation of genes involved in proliferation, whereas those with the intracellular domain of IR showed higher IRS-1 phosphorylation and stronger regulation of genes involved in metabolic pathways (14)
It is also thought to contribute to a number of health issues including cardiovascular diseases, Alzheimers, Parkinsons and diabetes
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Efficacy and safety of finerenone in patients with chronic kidney disease and type 2 diabetes by diuretic use: A FIDELITY analysis
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