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Similarly, the STEP 4 trial found that patients who discontinued semaglutide and switched to a placebo for 48 weeks regained 6.9% of their body weight

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Many patients find lukewarm food most tolerable

No matter the reason someone is using these medications, people might experience some gastrointestinal (GI) discomfort, including: Constipation Diarrhea Nausea Vomiting These side effects are most common when people first start treatment or after a recent dosage adjustment

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Some start medication with careful support