Individual results vary based on baseline weight, adherence to medication and lifestyle changes, genetics, and metabolic factors
Unlike some medications, GLP-1 agonists like semaglutide and tirzepatide do not require a medically mandatory taper there is no withdrawal syndrome or physical dependence risk in the traditional sense
Metabolic adaptation: After chronic dieting, stress, or poor sleep, your resting metabolism can slowso you burn fewer calories than expected
Gut microbiota and GLP-1
Potential reasons for this include: (1) 79% of our patients used a GLP-1 RA for an indication of diabetes rather than weight management, and (2) interactions with breast cancer treatments such as chemotherapy, chemotherapy supportive medications such as steroids, and/or endocrine therapy, which exacerbate metabolic dysfunction and contribute to weight gain, may attenuate weight loss with a GLP-1 RA
The popularity of Mounjaro for both diabetes and weight loss has led to increased demand and sometimes shortages