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doi: 10.1016/j.jhep.2015.08.038 [DOI] [PMC free article] [PubMed] [Google Scholar] 66.Gallego-Colon E, Klych-Ratuszny A, Kosowska A, et al

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Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output

The NICE recommendations tell GPs to consider testing in anyone with one symptom or one risk factor, and to treat early to prevent neurological damage that can become permanent