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In the Phase 2 trial protocol, participants reached the 12mg maximum dose at week 20 after five escalation steps (1mg, 2mg, 4mg, 8mg, 12mg), each held for four weeks

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[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Celsi F., Pizzo P., Brini M., Leo S., Fotino C., Pinton P., Rizzuto R