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In AD, cerebrovascular dysfunction occurs earlier among E4 carriers (Veitch et al., 2019), which could lead to impairments in nutrient sensing and metabolite exchange between the brain and periphery, thereby negatively impacting brain bioenergetics by rendering brain areas of high energetic needs (e.g., the hippocampus) vulnerable to pathologies such as amyloid (Veitch et al., 2019

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[DOI] [PubMed] [Google Scholar] 68.Kudin A.P., Baron G., Zsurka G., Hampel K.G., Elger C.E., Grote A., Weber Y., Lerche H., Thiele H., Nurnberg P., et al

The results of the parents ratings were similar, with both remedies showing an effect but MPH being significantly more effective on hyperactivity and inattention