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PTEN-induced putative kinase 1 (PINK1), a key protein in mitophagy, is processed in healthy mitochondria by TOM and TIM23 on the IMM

The increase of plasma long-chain ACs indicated that the fatty acid oxidation of depressed rats was incomplete, which may lead to a decrease in activities ( Table 1 Main information of pre-clinical researches studying the correlation between carnitine level and depression in animal

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Another emerging target is ceramide synthase 6 (CerS6), a key regulator of sphingolipid metabolism implicated in sterile inflammation

it requires levothyroxine replacement and careful TSH monitoring, not appetite-suppressing medications